cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy
Using state-of-the-art strategies, our results establish that cDC1s have a proatherogenic role in atherosclerosis by boosting CD4<sup>+</sup> and CD8<sup>+</sup> T-cell immunity and propose that cDC1s can be targeted with an immunosuppressive drug to decrease atherosclerosis progression.
Authors
- Elena Hernández‐García (ORCID: https://orcid.org/0000-0002-9018-5701)
- Almudena R. Ramiro (ORCID: https://orcid.org/0000-0002-7539-3844)
- Vanessa Núñez (ORCID: https://orcid.org/0000-0002-7473-1514)
- Ana Rodríguez-Ronchel (ORCID: https://orcid.org/0000-0003-1589-5831)
- Laura Fernández‐Méndez (ORCID: https://orcid.org/0000-0002-8783-2330)
- Susana Carregal‐Romero (ORCID: https://orcid.org/0000-0003-1444-6268)
- Stefanie K. Wculek (ORCID: https://orcid.org/0000-0001-5565-8561)
- Ana Dopazo (ORCID: https://orcid.org/0000-0002-4910-1684)
- Kenneth M. Murphy (ORCID: https://orcid.org/0000-0002-3505-9630)
- David Sancho (ORCID: https://orcid.org/0000-0003-2890-3984)
- Sandrine Henri (ORCID: https://orcid.org/0000-0002-8980-9193)
- Bernard Malissen
- Alberto Benguría (ORCID: https://orcid.org/0000-0002-5536-566X)
- Suin Jo (ORCID: https://orcid.org/0000-0002-7575-9017)
- Sarai Martínez-Cano (ORCID: https://orcid.org/0000-0001-5883-3900)
- Iñaki Robles‐Vera (ORCID: https://orcid.org/0000-0001-6002-9241)
- Elena Moya-Ruiz (ORCID: https://orcid.org/0000-0003-4157-5858)
- Jesús Ruı́z-Cabello (ORCID: https://orcid.org/0000-0001-8681-5056)
- Carlos Relaño‐Rupérez (ORCID: https://orcid.org/0000-0002-1407-9245)
- Tiantian Liu (ORCID: https://orcid.org/0000-0001-9377-9938)
- Miguel Á. Galán (ORCID: https://orcid.org/0000-0002-6695-1509)
- Manuel Rodrigo-Tapias (ORCID: https://orcid.org/0009-0009-6490-3114)
- Marcos Femenía-Muiña
- Pau Figuera-Belmonte
Institutions
- Université de Tours (FR)
- Ikerbasque (ES)
- Universidad Complutense de Madrid (ES)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of the Basque Country (ES)
- Universidad de Alcalá (ES)
- Washington University in St. Louis (US)
- CIC biomaGUNE (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Inmunotek (Spain) (ES)
- Centro de Investigación Biomédica en Red (ES)
- Institute for Research in Biomedicine (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Centre d’Immunologie de Marseille-Luminy (FR)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1161/circresaha.124.325792
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39