Enhancing Tissue Factor Production: The Role of N-Glycosylation and ERAD Pathway Modulation

Our findings underscore the crucial role of N-glycosylation in TF function and stability. Moreover, the modulation of the ERAD pathway through knocking out HRD1 presents a promising approach for enhancing TF production. These insights could contribute to the large-scale manufacturing of functionally active TF for clinical and research applications.

Authors

Yi‐Shi Liu (ORCID: https://orcid.org/0000-0001-5640-1899)
Hideki Nakanishi (ORCID: https://orcid.org/0000-0001-6968-2335)
Yue Dou (ORCID: https://orcid.org/0000-0001-6320-5482)
Xiaoman Zhou (ORCID: https://orcid.org/0000-0002-0270-2159)
Zijie Li (ORCID: https://orcid.org/0000-0002-5618-1862)

Institutions

Jiangnan University (CN)

Publication Details

Journal: Protein and Peptide Letters
Published: 2025-05-30
DOI: https://doi.org/10.2174/0109298665364078250519065417
Citations: 1
Primary Topic: Blood Coagulation and Thrombosis Mechanisms
Type: article
Field-Weighted Citation Impact: 1.77

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article

Enhancing Tissue Factor Production: The Role of N-Glycosylation and ERAD Pathway Modulation

Yi‐Shi Liu, Hideki Nakanishi, Yue Dou, Xiaoman Zhou et al.

May 30, 2025

1 citations

Protein and Peptide Letters

Blood Coagulation and Thrombosis Mechanisms

1.77

article

Enhancing Tissue Factor Production: The Role of N-Glycosylation and ERAD Pathway Modulation

Yi‐Shi Liu, Hideki Nakanishi, Yue Dou, Xiaoman Zhou, Zijie Li

May 30, 2025article en

1 citations

Abstract

Our findings underscore the crucial role of N-glycosylation in TF function and stability. Moreover, the modulation of the ERAD pathway through knocking out HRD1 presents a promising approach for enhancing TF production. These insights could contribute to the large-scale manufacturing of functionally active TF for clinical and research applications.

Protein and Peptide LettersVol. 32(7)

Jiangnan University (CN)

Openalex Percentile: Top 16%

Blood Coagulation and Thrombosis Mechanisms

1.77

DOI Source OpenAlex

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