Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model
MRF predominantly promotes the synthesis of Collagen I and Collagen III, increasing the Collagen I/III ratio, and regulates the expression of MMP-1, MMP-3, MMP-9, TGF-β, and EGF. These factors collectively drive fibroblast activation, migration, and ECM remodeling. These changes are indicative of the potential for MRF to support skin regeneration and rejuvenation. Preliminary findings suggest that ADSCs may contribute to these regenerative processes.
Authors
- Wanxin Zeng (ORCID: https://orcid.org/0000-0001-7825-8026)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-9281-9560)
- Xiang Wen (ORCID: https://orcid.org/0000-0003-0512-6502)
- Huimiao Tang
- Hao Wang (ORCID: https://orcid.org/0000-0003-0692-7037)
- Yidan Xu (ORCID: https://orcid.org/0009-0002-3783-4482)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Lasers in Surgery and Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1002/lsm.70033
- Citations
- 4
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- Education Department of Sichuan Province
- West China Hospital, Sichuan University