Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A
The upregulated miR-17-3p is associated with HbF in patients with β-thalassemia. Although miR-17-3p does not affect erythropoiesis, it promotes γ-globin expression by targeting BCL11A, suggesting that miR-17-3p may be a promising miRNA for the treatment of β-thalassemia.
Authors
- Meihuan Chen (ORCID: https://orcid.org/0000-0002-7356-8751)
- Liangpu Xu (ORCID: https://orcid.org/0000-0001-8815-2735)
- Siwen Zhang (ORCID: https://orcid.org/0009-0009-3994-5152)
- Hailong Huang
- Wantong Zhao (ORCID: https://orcid.org/0009-0006-7298-0150)
- Hua Cao (ORCID: https://orcid.org/0000-0001-8825-0175)
- Yanhong Zhang (ORCID: https://orcid.org/0000-0003-4412-5641)
- Junhao Zheng (ORCID: https://orcid.org/0000-0001-9124-2467)
- Jingmin Li (ORCID: https://orcid.org/0000-0002-0495-6996)
- Aixiang Lv
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13023-025-03806-0
- Citations
- 2
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Chinese People’s Liberation Army