Diffuse midline H3K27-altered glioma in an atypical location mimicking a medulloblastoma

This case highlights the importance of considering DMG, particularly with H3K27 alterations, as a differential diagnosis in posterior fossa tumors. The presence of these genetic mutations significantly impacts both treatment decisions and prognosis. The variability in clinical presentation and tumor morphology associated with DMG underscores the need for thorough evaluation to optimize treatment strategies and further our understanding of this complex entity.

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Publication Details

Journal
Surgical Neurology International
Published
2025-05-30
DOI
https://doi.org/10.25259/sni_238_2025
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Diffuse midline H3K27-altered glioma in an atypical location mimicking a medulloblastoma

Diego F. Sánchez, Romina Argañaraz, Yamila Basilotta Márquez, Juan Francisco Medina Gallardo
Surgical Neurology International
Glioma Diagnosis and Treatment
article

Diffuse midline H3K27-altered glioma in an atypical location mimicking a medulloblastoma

Diego F. Sánchez, Romina Argañaraz, Yamila Basilotta Márquez, Juan Francisco Medina Gallardo
article en

Abstract

This case highlights the importance of considering DMG, particularly with H3K27 alterations, as a differential diagnosis in posterior fossa tumors. The presence of these genetic mutations significantly impacts both treatment decisions and prognosis. The variability in clinical presentation and tumor morphology associated with DMG underscores the need for thorough evaluation to optimize treatment strategies and further our understanding of this complex entity.

Surgical Neurology InternationalVol. 16
Garrahan Hospital (AR)
Openalex Percentile: Top 82%
Glioma Diagnosis and Treatment
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