Alterations in White Matter Structure in Sleep-Related Epilepsies: A TBSS-Based Diffusion Tensor Imaging Study

The FA and RD values derived from DTI serve as neuroimaging markers to evaluate WM damage in SRE. These findings indicate that alterations in WM microstructure within the bilateral frontal lobes and corpus callosum may contribute to a potential pathophysiological mechanism underlying seizures in SRE. Furthermore, myelin damage appears to be more severe in early-onset SRE patients, highlighting the necessity for clinical vigilance regarding WM microstructural changes in young SRE patients.