Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation
Overall, our study revealed non-genetic mechanisms that enable bacterial strains to acquire adaptive imipenem-resistance rapidly. Moreover, preventing hospital-acquired infections should focus not only on eliminating residual bacteria but also on removing residual antibiotics in clinical settings.
Authors
- Rong Xu (ORCID: https://orcid.org/0000-0002-5510-3678)
- Weihua Yang (ORCID: https://orcid.org/0000-0002-7629-0193)
- Bo Yuan (ORCID: https://orcid.org/0000-0003-4437-5368)
- Yuan Tian (ORCID: https://orcid.org/0009-0006-3773-8131)
- Ying Zhou (ORCID: https://orcid.org/0000-0002-1546-0179)
- YunTao Luo (ORCID: https://orcid.org/0000-0001-6390-8639)
- QingZhong Wang (ORCID: https://orcid.org/0009-0003-7328-8762)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fcimb.2025.1563316
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59