Effect of Night Peeling With Azelaic Acid on Mature Facial Skin Parameters After 28 Days of Use: Preliminary Report

The aim of this study was to determine the effect of night peeling with azelaic acid (AA) on the parameters of mature facial skin after 28 days of use. The sample consisted of 28 participants (six participants did not complete the study for reasons unrelated to cosmetic intolerance), aged 40–68 years old, including both men and women, with dry and/or normal skin types, closed comedones, and visible signs of aging. The study lasted 28 days, during which all participants were evaluated before and after the treatment with the night peeling containing AA. The results showed that not all parameters changed significantly. Significant changes was observed in the skin moisture level (increased by 4%), skin elasticity (improved by 11%), and wrinkle length (reduced by 4%). In addition, it reduced wrinkle count by an average of 15%, wrinkle volume by an average of 8%, and wrinkle area by an average of 5%. These findings indicate a successful response to the night peeling treatment with AA. However, the study was relatively small in size and could be extended to include more subjects and investigate the use of the product over a longer period of time.