Osteoclast development from peripheral blood monocytes is reduced in patients with radiographic axial spondyloarthritis on biological therapy
Our study demonstrates that patients with r-axSpA exhibit a reduced capacity for osteoclast formation from CD14 + monocytes isolated from peripheral blood. The process was modulated by treatment with bDMARDs, which might explain the previously shown sparing effect of bDMARDs on bone mineral density in r-axSpA.
Authors
- Cecilia Engdahl (ORCID: https://orcid.org/0000-0002-8914-0178)
- Magnus Hallström (ORCID: https://orcid.org/0009-0009-4430-0228)
- Anna Deminger (ORCID: https://orcid.org/0000-0001-6423-1623)
- Helena Forsblad‐d’Elia (ORCID: https://orcid.org/0000-0001-7871-5303)
- Malin C. Erlandsson (ORCID: https://orcid.org/0000-0003-1100-7577)
Institutions
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13075-025-03578-9
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- Magnus Bergvalls Stiftelse
- Reumatikerförbundet
- Stiftelsen Reuma Forskningsfond Margareta