SNP-associated differential methylation in <i>ARHGEF38</i> : insights into genetic-epigenetic interactions
In this small sample size study, differential methylation in <i>ARHGEF38</i> was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the relevance of considering genetics when interrogating epigenetic mechanisms.
Authors
- John A. Wemmie (ORCID: https://orcid.org/0000-0001-7531-9065)
- Jacob J. Michaelson (ORCID: https://orcid.org/0000-0001-9713-0992)
- Jenny Gringer Richards
- Lucas G. Casten (ORCID: https://orcid.org/0000-0001-7690-6405)
- Jess G. Fiedorowicz (ORCID: https://orcid.org/0000-0003-2057-4071)
- Marie E. Gaine (ORCID: https://orcid.org/0000-0002-9196-0028)
- Aislinn Williams (ORCID: https://orcid.org/0000-0002-8139-2303)
- Vincent A. Magnotta (ORCID: https://orcid.org/0000-0001-8639-5354)
- Niamh Mullins (ORCID: https://orcid.org/0000-0001-8021-839X)
- Emese H. C. Kovács
Institutions
- University of Iowa (US)
- University of Ottawa (CA)
- Royal Ottawa Mental Health Centre (CA)
- MIND Research Institute (US)
- uOttawa Brain and Mind Research Institute
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1080/17501911.2025.2513215
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health
- National Center for Advancing Translational Sciences