Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing
This multicohort RNA-seq meta-analysis identified three biologically and clinically distinct sepsis endotypes characterized by coagulopathic, adaptive, and inflammatory responses. This endotype-based approach to patient stratification may facilitate the development of more precise therapeutic strategies for sepsis.
Authors
- Nobuyuki Hirohashi (ORCID: https://orcid.org/0000-0001-6237-214X)
- Kengo Mekata
- Modong Tan (ORCID: https://orcid.org/0000-0001-9966-631X)
- Michihito Kyo (ORCID: https://orcid.org/0000-0002-2559-6440)
- Nobuaki Shime (ORCID: https://orcid.org/0000-0002-9113-6151)
Institutions
- Hiroshima University (JP)
- IBM Research - Tokyo (JP)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s40560-025-00802-1
- Citations
- 5
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency