Prognostic markers in pheochromocytomas/paragangliomas: the role of histopathology, SDHB, MAML3 and MCM6 expression
Although there is still no definitive feature that predicts metastasis, in line with the literature, extra-adrenal localization, vascular invasion, capsular invasion, nuclear pleomorphism, hyperchromasia, and confluent necrosis were found to be associated with distant organ metastasis in our study. Additionally, in the multivariate analysis, larger tumor size (> 5.1 cm), the presence of > 3/10 HPF mitosis, and SDHB loss were associated with lower metastasis-free survival. While no conclusions could be drawn regarding MAML3, the prognostic value of MCM6 appears promising.
Authors
- Balça Begüm Cengiz (ORCID: https://orcid.org/0000-0001-8878-7837)
- Muzaffer Bilgin (ORCID: https://orcid.org/0000-0002-6072-6466)
- Emel Tekin (ORCID: https://orcid.org/0000-0001-7297-9869)
- Osman Furkan Mülkem (ORCID: https://orcid.org/0000-0001-9875-1985)
- Mustafa Fuat Açıkalın (ORCID: https://orcid.org/0000-0003-1708-467X)
Institutions
- Kütahya Dumlupınar Üniversitesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Eskişehir Osmangazi University (TR)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1007/s40618-025-02610-8
- Citations
- 1
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Eskişehir Osmangazi Üniversitesi