How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli
According to the results of this study, housing mice in IVCs appears to compromise welfare, altering behavioral, hormonal, and pain responses. This suggests that the IVC system can induce physiological and behavioral stress, potentially acting as a systemic confounding factor in mouse research.
Authors
- Efsun Kolatan (ORCID: https://orcid.org/0000-0003-4761-2779)
- Aslı Çelik (ORCID: https://orcid.org/0000-0002-2888-6080)
- Mehmet Ensari Güneli
- Cemre Ural (ORCID: https://orcid.org/0000-0002-4613-4528)
- Zahide Çavdar (ORCID: https://orcid.org/0000-0002-5457-198X)
- Mehmet Ateş (ORCID: https://orcid.org/0000-0002-8310-1979)
- Pembe Keskinoğlu (ORCID: https://orcid.org/0000-0002-3459-1828)
- Osman Yılmaz (ORCID: https://orcid.org/0000-0001-7817-7576)
Institutions
- Izmir University (TR)
- Dokuz Eylül University (TR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1002/brb3.70601
- Primary Topic
- Pharmacological Effects and Assays
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dokuz Eylül Üniversitesi