Assessment of redox balance parameters among patients with acute ischaemic stroke
Our findings demonstrate that an imbalance of oxidant and antioxidant status might play a role in the pathogenesis of IS. Patients in the initial phase of IS showed increased TOS, but no change in TAS, compared to healthy controls. This suggests effective initial antioxidant defence. TOS levels exhibited potential utility as clinical diagnostic biomarkers in patients with AIS. Although an imbalance towards oxidants may play a role in the pathogenesis of IS, these markers alone do not adequately predict stroke severity. Therefore, an analysis of the oxidant and antioxidant balance could play a crucial role in clarifying the pathogenic pathways of IS, presenting valuable diagnostic and prognostic tools, and identifying novel targets for antioxidant-focused therapies with neuroprotective agents.
Authors
- Agata Czarnowska (ORCID: https://orcid.org/0000-0003-2920-1271)
- Monika Grabia (ORCID: https://orcid.org/0000-0002-2230-9143)
- Katarzyna Kapica-Topczewska (ORCID: https://orcid.org/0000-0002-9720-3204)
- Agnieszka Mitrosz
- Katarzyna Socha (ORCID: https://orcid.org/0000-0002-5949-7061)
- Joanna Tarasiuk (ORCID: https://orcid.org/0000-0002-1238-8781)
- Joanna Kulikowska (ORCID: https://orcid.org/0000-0002-4808-7008)
- Jacek Jamiołkowski (ORCID: https://orcid.org/0000-0001-8442-9944)
- Anna Mirończuk (ORCID: https://orcid.org/0000-0001-9624-6299)
- Alina Kułakowska (ORCID: https://orcid.org/0000-0002-5458-2830)
- Monika Chorąży (ORCID: https://orcid.org/0000-0002-2222-8546)
- Jan Kochanowicz (ORCID: https://orcid.org/0000-0003-0382-6193)
- Paulina Matys (ORCID: https://orcid.org/0009-0002-1375-2415)
- Cezary Grunwald
- Dominika Jakubowicz Lachowska (ORCID: https://orcid.org/0000-0003-4114-1195)
Institutions
- Medical University of Białystok (PL)
Publication Details
- Journal
- Neurologia i Neurochirurgia Polska
- Published
- 2025-05-30
- DOI
- https://doi.org/10.5603/pjnns.104354
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00