Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells
Deep proteomic analysis revealed species-specific differences in transport-related proteins in the BBB. Furthermore, in vitro and in vivo differences were observed in the transporter and claudin protein expression. This study provides a BBB proteome profile dataset and offers insights for a comprehensive understanding of BBB protein expression across species and between in vivo and in vitro conditions.
Authors
- Tomomi Furihata (ORCID: https://orcid.org/0000-0003-3614-9328)
- Takeshi Masuda (ORCID: https://orcid.org/0000-0003-0121-4783)
- Sumio Ohtsuki (ORCID: https://orcid.org/0000-0003-4634-7133)
- Akihiro Toda
- Haruka Kumabe
- Norie Araki (ORCID: https://orcid.org/0000-0001-9987-6229)
- Shingo Ito (ORCID: https://orcid.org/0000-0002-8862-471X)
- Masayuki Mogi
Institutions
- Tokyo University of Pharmacy and Life Sciences (JP)
- Keio University (JP)
- Shin Nippon Biomedical Laboratories (Japan) (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12987-025-00650-z
- Citations
- 8
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science