Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extraction
This study showed that dictamnine (validated <i>in vitro</i> and <i>in vivo</i>) and pseudoephedrine (validated <i>in vitro</i>) may serve as potential H1R antagonists. This study offered valuable insights for future developments in antihistamines.
Authors
- Guizhou Hu
- Can Di
- Yuxuan Chen (ORCID: https://orcid.org/0000-0002-1269-1377)
- Xinqi Li (ORCID: https://orcid.org/0009-0008-8021-0791)
- Jin Qi
Institutions
- China Pharmaceutical University (CN)
- Kanion Pharmaceutical (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1601384
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00