Aggressive Neoplasms That Mimic Chronic Endodontic Lesions: A Multi‐Institutional Case Series
This study aimed to report sociodemographic, clinicopathologic and radiological features of 12 cases of aggressive neoplasms that were clinically diagnosed as chronic endodontic lesions. The series comprised seven females (58.33%) and five males (41.67%), with a mean age of 48.9 ± 19.19 years (range: 16-75 years). In six cases (50%), the posterior maxillary region was involved. Internal appearance was radiolucent density (n = 12/100%). Eleven cases (91.67%) exhibited well-defined borders, while one (8.33%) showed ill-defined borders. Histopathologic diagnoses included metastasis (n = 4/33.33%), squamous cell carcinoma (n = 3/25%), mucoepidermoid carcinoma (n = 2/16.68%), acinic cell carcinoma (n = 1/8.33%), Ewing's sarcoma (n = 1/8.33%) and Langerhans cell histiocytosis (n = 1/8.33%). Survival status was retrieved for three patients (25.00%), all of whom were alive at the time of reporting. This study identified seven distinct histological types of aggressive neoplasms that mimic chronic periapical lesions. Given that such lesions often lack clinical or radiological signs of aggressive behaviour, it is imperative that all excised tissue undergo histopathological examination.
Authors
- Ana Paula Neutzling Gomes (ORCID: https://orcid.org/0000-0003-2214-5246)
- Jean Nunes dos Santos (ORCID: https://orcid.org/0000-0001-7225-5879)
- G Mascarenhas (ORCID: https://orcid.org/0000-0002-5957-9024)
- Ana Carolina Uchôa Vasconcelos (ORCID: https://orcid.org/0000-0001-6560-9536)
- Lauren Frenzel Schuch (ORCID: https://orcid.org/0000-0002-0993-936X)
- Alejandra Moreno García (ORCID: https://orcid.org/0000-0001-7616-7948)
- Carolina Clasen Vieira (ORCID: https://orcid.org/0000-0003-4429-4760)
- Fernanda Geraldo Pappen (ORCID: https://orcid.org/0000-0002-8483-455X)
- Bernardo da Fonseca Orcina (ORCID: https://orcid.org/0000-0003-3367-483X)
- Alini Cardoso Soares (ORCID: https://orcid.org/0000-0001-6445-0658)
- Paulo Sérgio da Silva Santos (ORCID: https://orcid.org/0000-0003-1280-0817)
- Natália Gonçalves Macedo (ORCID: https://orcid.org/0000-0003-3621-8557)
Institutions
- Universidade Federal da Bahia (BR)
- Universidade do Estado da Bahia (BR)
- Universidade Federal de Pelotas (BR)
- Universidade de São Paulo (BR)
- Universidad de la República de Uruguay (UY)
Publication Details
- Journal
- Australian Endodontic Journal
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1111/aej.12956
- Citations
- 1
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico