Targeting casein kinase 2 and ubiquitin-specific protease 7 to modulate RUNX2-mediated osteogenesis in chronic kidney disease
CK2 activation promotes RUNX2 phosphorylation and stabilization by USP7, leading to improved osteogenesis and bone metabolism in CKD-MBD. Targeting the CK2/USP7/RUNX2 axis presents a potential therapeutic strategy for managing CKD-related bone disorders.
Authors
- Haifeng Lan (ORCID: https://orcid.org/0000-0002-7642-0576)
- Ming‐Liang He (ORCID: https://orcid.org/0000-0002-9942-9151)
- Yong Yang (ORCID: https://orcid.org/0000-0003-3306-1697)
- Guang‐Sheng Ling
- Yongjiang Yu (ORCID: https://orcid.org/0000-0002-4491-0079)
- Xiaojun Yu (ORCID: https://orcid.org/0009-0004-7164-7562)
- Ming Shao (ORCID: https://orcid.org/0000-0002-4989-1049)
- Yuwei Zeng
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s10020-025-01222-5
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Guangdong Medical Research Foundation