Behavior of test specificity under an imperfect gold standard: findings from a simulation study and analysis of real-world oncology data
New validation research, and review of existing validation studies, should consider the prevalence of the conditions assessed by a measure, and the possible impact on sensitivity and specificity of an imperfect gold standard.
Authors
- Lukas Slipski (ORCID: https://orcid.org/0000-0002-3196-8378)
- Mark S. Walker (ORCID: https://orcid.org/0000-0002-3276-2689)
- Yanina Natanzon (ORCID: https://orcid.org/0000-0002-9302-0304)
Institutions
- Concert Pharmaceuticals (United States) (US)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12874-025-02603-4
- Citations
- 2
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 6.26