Wnt/β-catenin regulates Gli1 + osteogenic progenitors in condylar subchondral bone development and osteoarthritis
Our findings establish Wnt/β-catenin signaling as a key regulator of Gli1 + progenitor cell fate determination in both bone development and TMJOA pathogenesis.
Authors
- Yi Zhang (ORCID: https://orcid.org/0000-0001-8170-9983)
- Yang He (ORCID: https://orcid.org/0000-0003-2862-1506)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7870-0646)
- Lin Sun
- Shuo Chen (ORCID: https://orcid.org/0000-0001-7426-3493)
Institutions
- National Clinical Research (US)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12891-025-08765-y
- Citations
- 1
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China