Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity
The established FRET-based HTS platform targeting 2C helicase facilitates anti-FMDV lead discovery, while 2C inhibitors may serve as an effective therapeutic strategy against other picornaviruses.
Authors
- Yang Tian (ORCID: https://orcid.org/0000-0003-2642-4760)
- Shanfa Yu (ORCID: https://orcid.org/0000-0003-4716-2878)
- Sijia Lü (ORCID: https://orcid.org/0000-0003-2469-1996)
- Hao Wu (ORCID: https://orcid.org/0000-0003-1197-2422)
- Suyu Mu (ORCID: https://orcid.org/0000-0001-6795-7710)
- Zhen Li (ORCID: https://orcid.org/0000-0001-8525-1922)
- Shiqi Sun (ORCID: https://orcid.org/0000-0003-4975-739X)
- Jiaying Zhao (ORCID: https://orcid.org/0000-0002-6009-0568)
- Yunfeng Song (ORCID: https://orcid.org/0000-0002-0954-152X)
- Huanchun Chen
- Saisai Zhou (ORCID: https://orcid.org/0009-0002-3253-0957)
Institutions
- Huazhong Agricultural University (CN)
- Lanzhou Veterinary Research Institute (CN)
- Chinese Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Viruses
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3390/v17060785
- Citations
- 1
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.90
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China