Multiplex imaging reveals novel patterns of MRTFA/B activation in the breast cancer microenvironment
Our results provide unique insights into how MRTFA and MRTFB promote metastasis in human cancer, the differences of their expression patterns, and their immune suppressive function within the breast cancer TME. Our results will guide future studies on targeting MRTFA/B transcriptional activity and the resulting immune suppression in breast cancer.
Authors
- Virgilia Macias (ORCID: https://orcid.org/0009-0003-2646-0064)
- Alexa M Gajda
- Mohamed Haloul
- Ekrem Emrah Er (ORCID: https://orcid.org/0000-0001-9456-9684)
- Zhengjia Chen (ORCID: https://orcid.org/0000-0002-6301-4931)
- Maria Sverdlov (ORCID: https://orcid.org/0000-0002-1893-865X)
- Kent Hoskins (ORCID: https://orcid.org/0000-0001-8712-0299)
- Xinyi Liu (ORCID: https://orcid.org/0009-0007-1893-4417)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0001-9447-4685)
- Elizabeth L. Wiley
- Kihak Lee
- S. Wilk
- CP Manzaneda Castillo
Institutions
- University of Illinois Urbana-Champaign (US)
- Illinois College (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12967-025-06559-3
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- University of Illinois at Urbana-Champaign
- National Cancer Institute
- Cancer Center, University of Illinois at Chicago
- Basic Research Laboratory