Delayed diagnosis of disseminated <i>Mycobacterium intracellulare</i> subsp. <i>chimaera</i> infective endocarditis via cell-free metagenomic next-generation sequencing: a case report
This case highlights that <i>M. intracellulare</i> subsp. <i>chimaera</i> infections may continue to emerge years after heater-cool unit discontinuation, suggesting that the time window for case incidence may still be active. cfmNGS may serve as a valuable diagnostic tool for disseminated <i>M. intracellulare</i> subsp. <i>chimaera</i>. Finally, we discuss pharmacotherapeutic factors, including the need for multiple agents over long durations, in this case with specific considerations given to the dissemination of infection into the central nervous system and potential drug-drug interactions, including steroids.
Authors
- Aaron Richterman (ORCID: https://orcid.org/0000-0001-7920-7191)
- Laurel Glaser (ORCID: https://orcid.org/0000-0001-8463-5107)
- Sonal Patel (ORCID: https://orcid.org/0000-0002-2012-8066)
- E Rodríguez (ORCID: https://orcid.org/0000-0002-6395-4157)
- Masood Anwar
- Pablo Tebas (ORCID: https://orcid.org/0000-0001-5345-7942)
- Edward F. Kreider (ORCID: https://orcid.org/0000-0003-2330-8430)
- Kyle G. Rodino (ORCID: https://orcid.org/0000-0001-9308-4810)
- Kelly Dyer (ORCID: https://orcid.org/0009-0006-2530-0191)
- Helen C. Koenig
- Joseph Benigno Ladines-Lim (ORCID: https://orcid.org/0000-0002-2461-2752)
- Wei-Teng Yang
- Judith A. O’Donnell
Institutions
- West Virginia School of Osteopathic Medicine (US)
- University of Pennsylvania Health System (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1128/asmcr.00003-25
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35