Cross-linking teichoic acids by click chemistry prevents bacterial cell growth
This work identifies a novel antibacterial mechanism that targets the cell wall of the human pathogen <i>Streptococcus pneumoniae</i>. Unlike conventional cell-wall targeting antibiotics, which inhibit the natural cross-linking of peptidoglycan, we introduce artificial cross-links in the other main component of the Gram-positive cell wall, the teichoic acids, and show that it leads to impaired cell growth.
Authors
- Anne Chouquet
- André Zapun (ORCID: https://orcid.org/0000-0001-8953-4399)
- Yung‐Sing Wong (ORCID: https://orcid.org/0000-0003-1038-9681)
- Morgane Baudoin (ORCID: https://orcid.org/0000-0002-9786-4416)
- Basile Pérès
- Cécile Morlot (ORCID: https://orcid.org/0000-0002-9295-1035)
- Cédric Laguri (ORCID: https://orcid.org/0000-0002-5429-6914)
- Claire Durmort (ORCID: https://orcid.org/0000-0001-5362-5061)
- Célia Boyat
Institutions
- Centre National de la Recherche Scientifique (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA Grenoble (FR)
- Institut de Biologie Structurale (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02577j
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- LABoratoires d’EXcellence ARCANE
- Agence Nationale de la Recherche
- Centre National de la Recherche Scientifique
- French Infrastructure for Integrated Structural Biology