Integrating Metabolomics and Gut Microbiota to Identify Key Biomarkers and Regulatory Pathways Underlying Metabolic Heterogeneity in Childhood Obesity
We identified distinct lipid disruptions characterizing obesity subtypes, including steroid/terpene deficits and sphingolipid/ether lipid dysregulation in the MUO/MHO groups as well as phospholipid imbalance (↑LPC/PS↓PE) in the OVOB/NOR groups. The gut microbiota exhibited a profile characterized by low diversity, an increased F/B ratio, and a reduced abundance of SCFA-producing genera. These findings suggest potential biomarkers for childhood obesity stratification, though further validation is warranted.
Authors
- Jing Sun (ORCID: https://orcid.org/0000-0001-9275-5424)
- Jiyong Yin
- Zhaolong Gong (ORCID: https://orcid.org/0000-0002-8564-5152)
- Zhiwei Xia (ORCID: https://orcid.org/0000-0001-8880-4617)
- Junsheng Huo (ORCID: https://orcid.org/0000-0002-9643-1897)
- Yan Li (ORCID: https://orcid.org/0000-0002-3568-2094)
- Liyuan Wang (ORCID: https://orcid.org/0000-0001-8513-1832)
- Tingting Liu (ORCID: https://orcid.org/0000-0003-0673-5254)
- Shi Shen (ORCID: https://orcid.org/0000-0002-9130-3984)
- Yi Yang (ORCID: https://orcid.org/0000-0003-1160-3627)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Beijing Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3390/nu17111876
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Chinese Center for Disease Control and Prevention