Gut Microbiome in Multiple Myeloma and Nutritional Interventions

In recent years, an amazing body of evidence highlights the link between the gut microbiome and the development of neoplastic diseases in humans.Numerous studies have focused on the interplay between gut microbiota, multiple myeloma and the influence of dietary factors on both.The aim of this review is to examine the contribution of the gut microbiome to the pathogenesis of multiple myeloma and to explore the role of nutrition in this context.Data were collected though a comprehensive search of published studies in reputable electronic databases, including PubMed and Google Scholar, supplemented by a thorough review of the relevant literature.Specific bacteria of the intestinal mucosa were found to proliferate in patients with multiple myeloma, while significant alterations in microbial diversity and complex metabolic interactions between gut microbes and the host were also observed.Additionally, a balanced and nutrient rich diet has the potential to support skeletal and immune system function.Current clinical research on the association between multiple myeloma and the gut microbiome remains limited.Nevertheless, understanding gut dysbiosis and its role in disease progression, as well as it is response to therapeutic interventions, is essential.Ultimately, dietary modifications and lifestyle interventions could reduce the risk of multiple myeloma or improve disease outcomes post diagnosis.