Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia

Objective. To measure the maternal serum cell free fetal DNA (CFFDNA) and establish the relationship between preeclampsia (PE) and maternal serum (CFFDNA) levels. Design and methods. A nested case-control study was carried out on 30 (PE) subjects and 30 matched controls aged 18–40 years old who were submitted at the Ain-S hams University maternity hospital. All subjects had a single viable fetus beyond 20-week gestational age. Upon enrollment, blood samples were collected, and the CFFDNA was subsequently measured in subjects and controls. Results. The CFFDNA level differed significantly between the analyzed groups, showing higher levels in PE diagnosed individuals than in controls. Additionally, the maternal serum CFFDNA level, utilizing an area under the curve of 0,979, predicted PE. Conclusion. Maternal serum cell free DNA can be utilized for PE prediction. The mean levels of CFFDNA correlate with developing maternal complications in PE.