High Transepidermal Water Loss at the Site of Wound Closure Is Associated With Increased Recurrence of Diabetic Foot Ulcers: The NIDDK Diabetic Foot Consortium TEWL Study
Compromised wound healing mechanisms culminating in wound closure associated with defective skin barrier function is associated with increased risk of DFU recurrence. Measurement of TEWL has value as a predictor of functional wound healing and could affect clinical practice, leading to better outcomes.
Authors
- Gayle M. Gordillo (ORCID: https://orcid.org/0000-0001-8369-6637)
- Geoffrey C. Gurtner (ORCID: https://orcid.org/0000-0001-6118-7161)
- Michael S. Conte (ORCID: https://orcid.org/0000-0001-9119-192X)
- Rodica Pop‐Busui (ORCID: https://orcid.org/0000-0002-2042-1350)
- Sashwati Roy (ORCID: https://orcid.org/0000-0002-9995-4917)
- Giselle E. Kolenic (ORCID: https://orcid.org/0000-0001-8705-9571)
- Crystal Holmes (ORCID: https://orcid.org/0009-0003-4316-3918)
- Shomita S. Mathew‐Steiner (ORCID: https://orcid.org/0000-0002-7730-9140)
- Cathie Spino (ORCID: https://orcid.org/0000-0002-6157-6738)
- Chandan K. Sen (ORCID: https://orcid.org/0000-0003-3151-5202)
- Teresa L.Z. Jones (ORCID: https://orcid.org/0000-0001-8278-2322)
- Mithun Sinha (ORCID: https://orcid.org/0000-0002-9222-1921)
- Jordan Jahnke
- Lava Timsina (ORCID: https://orcid.org/0000-0001-7493-5843)
Institutions
- University of Arizona (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- University of Michigan (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- McGowan Institute for Regenerative Medicine (US)
- International Drug Development (FR)
- Statistical Research (United States) (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Stanford University (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-05-30
- DOI
- https://doi.org/10.2337/dc25-0300
- Citations
- 11
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 14.24
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases