Kinetic modeling of 18F-PI-2620 binding in the brain using an image-derived input function with total-body PET
This study demonstrated the utility of IDIF from a lager blood pool, derived using the total-body PET in quantifying <sup>18</sup>F-PI-2620 kinetics in the brain. Our findings suggest that a 60-minute scan window may be required for the reliable quantification of kinetic parameters using IDIF, whereas a 30-minute scan time may be sufficient for the quantification of K<sub>1</sub>.
Authors
- Charles DeCarli
- Emily Nicole Holy (ORCID: https://orcid.org/0009-0000-9420-9195)
- Audrey P. Fan (ORCID: https://orcid.org/0000-0001-5850-6117)
- Anjan Bhattarai (ORCID: https://orcid.org/0000-0002-9178-6509)
- Guobao Wang (ORCID: https://orcid.org/0000-0001-6526-1533)
- Yiran Wang (ORCID: https://orcid.org/0000-0002-8381-8769)
- Benjamin A. Spencer
Institutions
- University of California, Davis (US)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13550-025-01260-4
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36