Severe Pernicious Anemia: A Case Report

Pernicious anemia is an infrequent condition and a recognized cause of vitamin B12 deficiency. It is an autoimmune disease that impairs the absorption of vitamin B12, leading to a significant reduction in its uptake. Clinical manifestations are often subtle and non-specific, yet potentially debilitating, which may delay diagnosis. However, with early recognition in primary care and appropriate replacement therapy, patients can recover their quality of life. Fatigue and asthenia are common complaints in primary care, highlighting the importance of careful clinical evaluation in the presence of nonspecific symptoms. Timely laboratory investigations are essential for the early detection of the disease and the prevention of serious complications.

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Publication Details

Journal
Cureus
Published
2025-05-30
DOI
https://doi.org/10.7759/cureus.85088
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Severe Pernicious Anemia: A Case Report

Leonor Simões Raposo, Adriana Pacheco, Eugénia Mendes
Cureus
Folate and B Vitamins Research
article

Severe Pernicious Anemia: A Case Report

Leonor Simões Raposo, Adriana Pacheco, Eugénia Mendes
article en

Abstract

Pernicious anemia is an infrequent condition and a recognized cause of vitamin B12 deficiency. It is an autoimmune disease that impairs the absorption of vitamin B12, leading to a significant reduction in its uptake. Clinical manifestations are often subtle and non-specific, yet potentially debilitating, which may delay diagnosis. However, with early recognition in primary care and appropriate replacement therapy, patients can recover their quality of life. Fatigue and asthenia are common complaints in primary care, highlighting the importance of careful clinical evaluation in the presence of nonspecific symptoms. Timely laboratory investigations are essential for the early detection of the disease and the prevention of serious complications.

CureusVol. 17(5)
Western NSW Local Health District (AU), Instituto Nacional de Administração, I. P. (PT)
Openalex Percentile: Top 81%
Folate and B Vitamins Research
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Severe Pernicious Anemia: A Case Report — Leonor Simões Raposo, Adriana Pacheco, et al. · Cureus (2025) | TGRS Research Map | TGRS