Gold(<scp>i</scp>) and gold(<scp>iii</scp>) complexes of triazolyl-functionalised NHCs
Novel triazolyl-functionalised imidazolium salts and their corresponding Au<sup>I</sup>/Au<sup>III</sup> complexes were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The reaction of (mono and bis carbene) Au<sup>I</sup> complexes with thionyl chloride gave Au<sup>III</sup> complexes. These Au<sup>III</sup> complexes are reduced to Au<sup>I</sup> complexes by DMSO dissolution, and react with silver nitrate to afford chelating complexes, where the triazolyl N atoms bind to gold. The triazolyl-functionalised Au<sup>I</sup> complexes showed potency against ovarian cancer cells (OVCAR-8 cells, IC<sub>50</sub> < 15 μM).
Authors
- Hani Al‐Salami (ORCID: https://orcid.org/0000-0003-0049-6969)
- Stephen A. Moggach (ORCID: https://orcid.org/0000-0001-5339-7070)
- Karrar Al‐Ameed (ORCID: https://orcid.org/0000-0002-8333-3868)
- Murray V. Baker (ORCID: https://orcid.org/0000-0002-0482-3421)
- Vito Ferro (ORCID: https://orcid.org/0000-0003-3306-2550)
- Hawraa S. Al‐Buthabhak (ORCID: https://orcid.org/0000-0003-1676-9554)
- Alexandre N. Sobolev (ORCID: https://orcid.org/0000-0003-3290-2044)
- Yu Yu (ORCID: https://orcid.org/0000-0002-0209-0586)
Institutions
- The University of Queensland (AU)
- The University of Western Australia (AU)
- Curtin University (AU)
- University of Kerbala (IQ)
- University of Warith Al-Anbiyaa
- University of Kufa (IQ)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra02655e
- Citations
- 4
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- European Commission
- University of Queensland
- Curtin University of Technology
- University of Western Australia
- Higher Committee for Education Development in Iraq
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Horizon 2020