Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning
These studies combined a series of behavior assays in a phenotypically rich, rapid, and inexpensive non-mammalian vertebrate test system to screen chemicals for neurotoxicity. Together with <i>in silico</i> target predictions and mouse- and human-based models, our findings establish multi-behavioral phenotyping in zebrafish as a powerful toolkit for neurotoxicity testing and mechanism identification, with relevance for humans. https://doi.org/10.1289/EHP16568.
Authors
- Jana Nerlich (ORCID: https://orcid.org/0000-0002-6450-6380)
- Stefan Hallermann (ORCID: https://orcid.org/0000-0001-9376-7048)
- Kristina Bartmann (ORCID: https://orcid.org/0000-0002-1988-9140)
- Tamara Tal (ORCID: https://orcid.org/0000-0001-8365-9385)
- Nicole Schweiger (ORCID: https://orcid.org/0009-0005-2393-0774)
- Ellen Fritsche (ORCID: https://orcid.org/0000-0002-7454-679X)
- N. Herold (ORCID: https://orcid.org/0000-0002-9954-5355)
- David Leuthold (ORCID: https://orcid.org/0000-0001-8326-3831)
- Ilka Scharkin (ORCID: https://orcid.org/0009-0008-2729-3823)
Institutions
- Helmholtz Centre for Environmental Research (DE)
- University of Basel (CH)
- Leibniz Institute of Environmental Medicine (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1289/ehp16568
- Citations
- 5
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.76
Funders
- European Commission
- HORIZON EUROPE Framework Programme