Light-Activated Hypoxia-Responsive Nanoparticles for Photodynamic Chemotherapy
Hypoxia is a characteristic of solid tumors, and it significantly impedes cancer treatment. Here, we report light-activated hypoxia-responsive nanoparticles NPs-TPZ consisting of 5,10,5,20-tetrakis-(4-aminophenyl)-porphine (TAPP) modified with four azobenzene groups, cyclodextrin (CD), and 3-aminobenzotriazine-1,4-di-N-oxide tirapazamine (TPZ) by the synergy of π-π stacking, host-guest, and hydrophobic interactions for synergistic photodynamic chemotherapy (PDT-CT). Under near-infrared (NIR) irradiation, the process of PDT depletes oxygen and generates singlet oxygen (<sup>1</sup>O<sub>2</sub>). The induced hypoxia exacerbation further accelerates the release and activation of TPZ. As a result, this hypoxia-responsive nanoparticle provides an effective strategy for the ablation of hypoxic solid tumors by synergistic PDT-CT.
Authors
- Yue Ding (ORCID: https://orcid.org/0000-0002-8857-4855)
- Suqing Zheng (ORCID: https://orcid.org/0000-0001-7247-238X)
- Fengming Liang (ORCID: https://orcid.org/0009-0003-2004-9899)
- Dan Zhao (ORCID: https://orcid.org/0000-0002-3231-267X)
- Xinyi Zuo
- Hongyang Xu
Institutions
- Nantong University (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1021/acsomega.4c11283
- Citations
- 3
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Natural Science Foundation of Jiangsu Province
- Science and Technology Project of Nantong City