Outside Back Cover: Tandem Dual‐Ratiometric SERS Probe Enables Raman Imaging of Neurological pH Fluctuations in Epilepsy (Angew. Chem. Int. Ed. 25/2025)
Dynamic monitoring of pH fluctuations within brain lesions in real time offers a promising strategy for elucidating how local acidosis contributes to neuronal hyperexcitability and the evolution of neurological disease. In their Research Article (e202504822), Cong Wang, Cong Li et al. report a precisely engineered monolayer self-assembly approach that greatly improves the signal intensity and photostability of SERS-based imaging. Leveraging this platform, they construct a tandem dual-ratiometric SERS probe capable of accurate and dynamic digital decoding of pH within diseased brain tissue, providing new insight into the microenvironmental cues that shape disease progression.
Authors
- Xihui Gao (ORCID: https://orcid.org/0000-0002-2149-0008)
- Qinyue Wang
- Zuhai Lei (ORCID: https://orcid.org/0000-0001-6851-6044)
- Yahong Zhang (ORCID: https://orcid.org/0000-0003-1148-949X)
- Yuncan Chen
- Cong Li (ORCID: https://orcid.org/0000-0001-7731-8031)
- Cong Wang (ORCID: https://orcid.org/0000-0002-2236-4636)
- Bohan Li (ORCID: https://orcid.org/0000-0002-1435-696X)
- Junfeng Wang (ORCID: https://orcid.org/0009-0007-4494-2170)
- Jian Zhao (ORCID: https://orcid.org/0000-0002-8862-0591)
- Yurui Tang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Academy of Mathematics and Systems Science (CN)
- Precision Research (United States) (US)
- Huashan Hospital (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1002/anie.202511457
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00