RNA profiling and immunohistochemistry analyses of circRNAs in imatinib-resistant gastrointestinal stromal tumors
Our results demonstrated that the circRNA in situ hybridization-immunohistochemistry could not only be applied to FFPE-TMAs for high-throughput analysis of circRNA expression in tumors but also suggested a possible role for circ-BRIP1, circ-EPHB4, and their host genes in the progression of GISTs.
Authors
- Huaqin Sun (ORCID: https://orcid.org/0000-0002-4548-4657)
- Xiaomeng He (ORCID: https://orcid.org/0000-0002-5254-4005)
- Wenyang Li (ORCID: https://orcid.org/0000-0001-6078-6357)
- Ning Jia (ORCID: https://orcid.org/0000-0002-0672-454X)
- Christopher Corpe (ORCID: https://orcid.org/0000-0003-1994-8312)
- Qiuyue Li (ORCID: https://orcid.org/0000-0003-0058-503X)
- Jin Wang (ORCID: https://orcid.org/0000-0002-0062-2489)
- Jingjing Xu (ORCID: https://orcid.org/0000-0003-4501-1793)
- Hanxing Tong (ORCID: https://orcid.org/0000-0001-5227-3711)
Institutions
- Tongji University (CN)
- Sun Yat-sen University (CN)
- King's College London (GB)
- Xiamen University (CN)
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Hexi University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12967-025-06598-w
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province