Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study

Our MR analysis did not support a causal relationship between periodontitis and oral cancer. Preventing and treating acute or chronic periodontitis may not reduce the oral cancer risk, and the advantages of screening patients for periodontitis for early cancer detection are limited, which may provide assistance in reducing clinical inputs. This study bears some limitations including inapplicable method if the relationship is non-linear. Analyzing statistical data in a database stratified by sex or age is difficult, potentially leading to biased results.