Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression
This study identified R2 as a regulator of STAT3 with dual antifibrotic effects: reduction of the inflammatory microenvironment and induction of senescence. These findings position R2 as a viable treatment candidate for HF, necessitating additional clinical investigation.
Authors
- Kaili Deng (ORCID: https://orcid.org/0000-0003-1823-9960)
- Min Li (ORCID: https://orcid.org/0000-0003-1330-2326)
- Haotian Shi (ORCID: https://orcid.org/0000-0001-8222-8196)
- Zhiping Lv (ORCID: https://orcid.org/0000-0003-2796-526X)
- Liangliang Xiang
- Jiayi Cheng (ORCID: https://orcid.org/0000-0002-4262-9136)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-9143-8029)
- Sha Huang (ORCID: https://orcid.org/0000-0003-2589-5181)
- Yuhua Wang (ORCID: https://orcid.org/0000-0001-7047-4760)
Institutions
- Southern Medical University (CN)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1016/j.jgr.2025.05.007
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35