Chimeric antigen receptors discriminate between tau and distinct amyloid-beta species
Our findings demonstrate that CARs can detect and discriminate between tau PFFs, Aβ1-42, and Aβp3-42 aggregates. This highlights the potential of repurposing AD antibodies for CAR-based therapies to selectively target tau NFTs and distinct forms of Aβ senile plaques.
Authors
- Cynthia J. Siebrand (ORCID: https://orcid.org/0000-0001-5422-1835)
- Suckwon Lee
- Julie K. Andersen (ORCID: https://orcid.org/0000-0003-1324-4875)
- Chaska C. Walton (ORCID: https://orcid.org/0000-0001-8513-0207)
- Nicholas J. Bergo
Institutions
- University of Southern California (US)
- Buck Institute for Research on Aging (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12967-025-06572-6
- Citations
- 7
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Institutes of Health
- National Institute on Aging