Intrasplenic Transplantation of Islets With a Platelet Shielding System Restores Glycemic Control
Instant blood-mediated inflammatory reactions (IBMIRs) and low extracellular matrix (ECM) concentrations hinder islet implantation and survival in the spleen. Islets were encapsulated in hepatocytes and fibroblasts. The low expression of von Willebrand factor in hepatocytes enables them to form a protective coating with fibroblasts. This coating reduces IBMIRs and supports islet survival through ECM production by fibroblasts. The hepatocyte-fibroblast encapsulation significantly reduces islet mortality during the posttransplantation stress period, enabling rapid engraftment and vascularization in the spleen.
Authors
- Yanjiao Teng
- Anqi Yang
- Xiaocong Kuang
- Lei Dong (ORCID: https://orcid.org/0000-0002-2013-4191)
- Xuyong Sun (ORCID: https://orcid.org/0009-0008-1980-0098)
- Chunming Wang (ORCID: https://orcid.org/0000-0001-9185-9678)
- Lin Song (ORCID: https://orcid.org/0000-0003-0728-7780)
- Xintong Wang (ORCID: https://orcid.org/0009-0006-0682-896X)
- Decheng Lü
- Chunyan Liu (ORCID: https://orcid.org/0000-0002-2533-7617)
- Xiaohai Zhang
Institutions
- Nanjing Tech University (CN)
- Guangxi University (CN)
- Guangxi Medical University (CN)
- China Pharmaceutical University (CN)
- Tianjin University (CN)
- University of Macau (MO)
- Yulin Normal University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
- Wuxi Institute of Technology (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-05-30
- DOI
- https://doi.org/10.2337/db24-0856
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- United Mitochondrial Disease Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Universidade de Macau