Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling
Notably, kinase-substrate enrichment analysis identified CSNK2A1 and PRKACA as potential response kinases, whereas their transcription and protein levels were experimentally validated to be significantly altered after VZV infection, showing the same trend. Furthermore, Mendelian randomization (MR) analysis revealed that decreased expression of CSNK2A1 may lead to a higher risk of HZ, indicating a vital role of this kinase during anti-VZV infection. Collectively, our findings provide valuable insights into the molecular mechanisms underlying VZV infection and highlight potential therapeutic targets for further investigation.
Authors
- Yiping Dong (ORCID: https://orcid.org/0000-0002-4601-370X)
- Wei Li (ORCID: https://orcid.org/0000-0002-5291-3421)
- Jing Xia (ORCID: https://orcid.org/0000-0002-1009-3074)
- Tianyu Zhang (ORCID: https://orcid.org/0000-0001-5647-6014)
- Zhong‐Liang Deng (ORCID: https://orcid.org/0000-0001-5330-3062)
- Mei Yang (ORCID: https://orcid.org/0000-0002-7584-9370)
- Hongxiang Xu (ORCID: https://orcid.org/0000-0003-1388-5218)
- Xinpei Wang (ORCID: https://orcid.org/0000-0002-1616-171X)
Institutions
- Southwest University (CN)
- Army Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Third People 's Hospital of Chongqing (CN)
- Ministry of Education (BD)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/idr.s516945
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00