Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors
Results of our single-center study suggest that IPFT can be safely adopted by small and mid-sized clinical centers, as the risk of bleeding is low. The results of coadministering tPA and DNase are safe, and it reduces the need for surgical intervention in nearly one-third of patients.
Authors
- Nisarfathima Kazimuddin
- Roshan Acharya (ORCID: https://orcid.org/0000-0002-3794-2582)
- Fawaz Mohammed (ORCID: https://orcid.org/0000-0001-9256-3641)
- I. Waheed
- R. Steff
- Karan Singh (ORCID: https://orcid.org/0000-0002-0179-6763)
- Nada Qaisar Qureshi (ORCID: https://orcid.org/0000-0002-7589-6695)
- Akinchan Kafle (ORCID: https://orcid.org/0000-0003-3160-5478)
- Yub Raj Sedhai (ORCID: https://orcid.org/0000-0002-1755-5489)
- Tahir Muhammad Abdullah Khan (ORCID: https://orcid.org/0000-0002-2065-3055)
- Muhammad Altaf Ahmed
- Priyanka Bhat
Institutions
- University of Kentucky (US)
- Tribhuvan University (NP)
- Carilion Clinic (US)
- Western Kentucky University (US)
Publication Details
- Journal
- Therapeutic Advances in Respiratory Disease
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/17534666251343711
- Citations
- 2
- Primary Topic
- Pleural and Pulmonary Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04