Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C‐mutated advanced non‐small cell lung cancer

This study demonstrated that early clearance of KRAS G12C-mutant ctDNA predicted the clinical benefit of sotorasib in patients with advanced NSCLC, suggesting that dynamic monitoring of ctDNA levels also may anticipate sotorasib resistance.

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Publication Details

Journal
Cancer
Published
2025-05-30
DOI
https://doi.org/10.1002/cncr.35917
Citations
5
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
4.68
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article

Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C‐mutated advanced non‐small cell lung cancer

Francesco Passiglia, Silvia Novello, Edoardo Garbo, Paola Bordi et al.
5 citations
Cancer
Cancer Genomics and Diagnostics
4.68
article

Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C‐mutated advanced non‐small cell lung cancer

Francesco Passiglia, Silvia Novello, Edoardo Garbo, Paola Bordi, Umberto Malapelle, Chiara Ambrogio, Lucia Palumbo, Roberta Minari, Giancarlo Troncone, Massimiliano Cani, Luisella Righi, Monica Pluchino, Enrica Capelletto, Claudia Scimone, Francesco Pepe, Maurizio Balbi, Riccardo Taulli, Antonio Ungaro, Angela Listì, Diana Giannarelli, Gianluca Russo, Federica Benso, Marcello Tiseo
article en
5 citations

Abstract

This study demonstrated that early clearance of KRAS G12C-mutant ctDNA predicted the clinical benefit of sotorasib in patients with advanced NSCLC, suggesting that dynamic monitoring of ctDNA levels also may anticipate sotorasib resistance.

CancerVol. 131(11)
University of Parma (IT), Agostino Gemelli University Polyclinic (IT), Azienda Ospedaliera S.Giuseppe Moscati (IT), Ospedale San Luigi Gonzaga (IT), University of Turin (IT)
Good health and well-being
Openalex Percentile: Top 5%
Cancer Genomics and Diagnostics
4.68
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