Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C‐mutated advanced non‐small cell lung cancer
This study demonstrated that early clearance of KRAS G12C-mutant ctDNA predicted the clinical benefit of sotorasib in patients with advanced NSCLC, suggesting that dynamic monitoring of ctDNA levels also may anticipate sotorasib resistance.
Authors
- Francesco Passiglia (ORCID: https://orcid.org/0000-0002-0244-5738)
- Silvia Novello (ORCID: https://orcid.org/0000-0001-7653-9748)
- Edoardo Garbo (ORCID: https://orcid.org/0000-0003-2394-9895)
- Paola Bordi (ORCID: https://orcid.org/0000-0001-6994-7399)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Chiara Ambrogio (ORCID: https://orcid.org/0000-0003-4122-701X)
- Lucia Palumbo (ORCID: https://orcid.org/0000-0002-6206-0266)
- Roberta Minari (ORCID: https://orcid.org/0000-0002-4808-0308)
- Giancarlo Troncone (ORCID: https://orcid.org/0000-0003-1630-5805)
- Massimiliano Cani (ORCID: https://orcid.org/0000-0001-9608-4840)
- Luisella Righi (ORCID: https://orcid.org/0000-0002-8927-204X)
- Monica Pluchino
- Enrica Capelletto (ORCID: https://orcid.org/0000-0003-2070-9335)
- Claudia Scimone (ORCID: https://orcid.org/0009-0000-5623-121X)
- Francesco Pepe (ORCID: https://orcid.org/0000-0002-2803-9586)
- Maurizio Balbi (ORCID: https://orcid.org/0000-0002-8436-3655)
- Riccardo Taulli (ORCID: https://orcid.org/0000-0003-1277-6263)
- Antonio Ungaro (ORCID: https://orcid.org/0000-0003-0548-2611)
- Angela Listì (ORCID: https://orcid.org/0000-0002-0617-6184)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Gianluca Russo (ORCID: https://orcid.org/0000-0003-2698-9470)
- Federica Benso (ORCID: https://orcid.org/0009-0009-2696-7387)
- Marcello Tiseo
Institutions
- University of Parma (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Ospedale San Luigi Gonzaga (IT)
- University of Turin (IT)
Publication Details
- Journal
- Cancer
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1002/cncr.35917
- Citations
- 5
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.68