Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply
Administration of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) increases splanchnic blood flow. We investigated the role of endogenous GIP in splanchnic blood flow regulation using a receptor antagonist in humans. Oral glucose ingestion increased blood flow in the superior mesenteric artery by ∼70%, and the increase was significantly lower during concurrent infusion of the GIP receptor antagonist. Thus, endogenous GIP contributed ∼22% of the postprandial increase in superior mesenteric artery blood flow. We have identified a novel physiological aspect of vascular biology related to the GIP receptor in humans. Treatments targeting the GIP receptors are likely to affect splanchnic blood flow.
Authors
- Kirsa Skov‐Jeppesen (ORCID: https://orcid.org/0000-0002-8861-6699)
- Henrik Larsson (ORCID: https://orcid.org/0000-0002-1348-7749)
- METTE MARIE ROSENKILDE (ORCID: https://orcid.org/0000-0001-9600-3254)
- Lærke S. Gasbjerg (ORCID: https://orcid.org/0000-0002-7880-8515)
- Bolette Hartmann (ORCID: https://orcid.org/0000-0001-8509-2036)
- Ulrik B. Andersen (ORCID: https://orcid.org/0000-0003-2214-0496)
- Bryan Haddock (ORCID: https://orcid.org/0000-0002-9721-4712)
- Rasmus Syberg Rasmussen (ORCID: https://orcid.org/0000-0002-5892-7859)
- Sophie W. Nielsen
- Ali Asmar (ORCID: https://orcid.org/0000-0002-0530-827X)
- Jens Juul Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
- Helle Hjorth Johannesen (ORCID: https://orcid.org/0000-0001-9172-5004)
- Mark Bitsch Vestergaard (ORCID: https://orcid.org/0000-0002-9737-9672)
- Frederikke Østergaard
- Ludvig S. Langberg
Institutions
- University of Copenhagen (DK)
- Novo Nordisk Foundation (DK)
- Frederiksberg Hospital (DK)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University College Copenhagen (DK)
- IT University of Copenhagen (DK)
Publication Details
- Journal
- Diabetes
- Published
- 2025-05-30
- DOI
- https://doi.org/10.2337/db25-0149
- Citations
- 3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Hørslev-Fonden
- Den A. P. Møllerske Støttefond
- European Foundation for the Study of Diabetes
- Novo Nordisk
- Rigshospitalet
- Region Hovedstaden
- Kong Christian den Tiendes Fond
- Novo Nordisk Fonden