The influence of the Big Five inventory on quality of life in people with Parkinson’s disease aged 50 and above: A Longitudinal Analysis from the Survey of Health, Aging and Retirement in Europe (SHARE)

Neuroticism plays a pivotal role in predicting QoL decline in PwPD, highlighting its utility as a target for psychological interventions aimed at emotional regulation and resilience building. While depressive symptoms and mobility limitations also contribute, integrating personality assessments into care strategies may improve outcomes. These findings advocate for a multidimensional approach to managing PD that addresses both clinical and psychological factors.