Bimodal distributions of anti-Trypanosoma cruzi antibody levels in blood donors are associated with parasite detection and antibody waning in peripheral blood
Ab reactivity is associated with PCR-detectable parasitemia. Greater Ab declines were detected among donors with low and/or discordant Ab reactivity and negative PCR results, suggesting spontaneous parasite clearance in these donors.
Authors
- Mirta Remesar (ORCID: https://orcid.org/0000-0002-5656-1144)
- Mónica G. López
- Marcelo Martins Pinto Filho (ORCID: https://orcid.org/0000-0002-6646-1163)
- Sonia Bakkour Coco (ORCID: https://orcid.org/0000-0001-8773-0740)
- Clara Di Germanio (ORCID: https://orcid.org/0000-0002-6047-211X)
- Éster Cerdeira Sabino (ORCID: https://orcid.org/0000-0003-2623-5126)
- C.A. Merlo
- Ana Emilia del Pozo
- Lewis Buss (ORCID: https://orcid.org/0000-0002-9009-9301)
- Antônio Luiz Pinho Ribeiro (ORCID: https://orcid.org/0000-0002-2740-0042)
- Léa Assed Bezerra da Silva (ORCID: https://orcid.org/0000-0001-7118-6859)
- M.P. Busch
- Sebastián L. Humeres
- Héctor A. Pavón
Institutions
- University of California, San Francisco (US)
- Garrahan Hospital (AR)
- Pacific Research Institute (US)
- National University of the Northeast (AR)
- University of Bristol (GB)
- Centro Científico Tecnológico - Nordeste (AR)
- Vitalant (US)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (BR)
- Ministerio de Salud - Provincia de Buenos Aires (AR)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1371/journal.pntd.0012724
- Citations
- 1
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Foundation for the National Institutes of Health