3-Deoxysappanchalcone attenuates LPS-induced neuroinflammation in microglia cell culture and ameliorates cognitive impairment in traumatic brain injury
Collectively, these findings suggest that 3-DSC holds promise as a potential compound for the development of therapeutic and preventive agents aimed at treating neuroinflammation-related disorders. It offers a new avenue for further research and potential clinical applications in the context of TBI and neuroinflammation related disorders.
Authors
- Yueyang Chen (ORCID: https://orcid.org/0000-0002-4390-550X)
- Yunfeng Diao (ORCID: https://orcid.org/0000-0002-9455-1510)
- Yatao Wang (ORCID: https://orcid.org/0009-0002-2541-3795)
- Maohua Zheng
- Dianxu Ren (ORCID: https://orcid.org/0000-0002-1160-8922)
- Jianwei Li (ORCID: https://orcid.org/0000-0002-0429-3627)
- Qu Yang
- Hongtao Sun (ORCID: https://orcid.org/0000-0001-8621-3215)
- Zhongxin Li (ORCID: https://orcid.org/0000-0002-6375-1667)
- Jingjing Wang (ORCID: https://orcid.org/0009-0001-5376-8836)
Institutions
- First Hospital of Lanzhou University (CN)
- Chinese People's Armed Police Force
- Lanzhou University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1371/journal.pone.0323259
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China