School-aged Schistosoma mansoni infection levels after long-term programmatic control show failure to meet control programme targets and evidence of a persistent hotspot: evaluation of the FibroScHot trial baseline data
The criteria for persistent hotspots were met in the high transmission but not the moderate transmission community despite neither community meeting the threshold of morbidity control. This disconnect indicates that endemic communities exist in which control has not been achieved but increased frequency of treatment is currently not recommended. FibroScHot will be able to inform on whether widening the current recommendation of increased treatment frequency to these communities will achieve improved control. Evidence provided also indicates scope for the integrated control strategies of vector control and WASH improvements in both the participating communities.
Authors
- Fredrick Jones Muyodi (ORCID: https://orcid.org/0000-0002-0651-4948)
- Fred Nuwaha (ORCID: https://orcid.org/0000-0001-6285-0834)
- John Joseph Kisakye
- Edridah M. Tukahebwa (ORCID: https://orcid.org/0000-0002-0624-2890)
- Shona Wilson (ORCID: https://orcid.org/0000-0001-5725-4376)
- Birgitte J. Vennervald (ORCID: https://orcid.org/0000-0001-5721-3494)
- Moses Adriko (ORCID: https://orcid.org/0000-0001-9748-1207)
- Rowel Candia (ORCID: https://orcid.org/0000-0001-8634-5285)
- Fred Besigye (ORCID: https://orcid.org/0000-0002-9179-8606)
- Rosemary Nalwanga
Institutions
- University of Cambridge (GB)
- Mulago Hospital (UG)
- Ministry of Health (UG)
- Institute of Parasitology (CZ)
- Makerere University (UG)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1371/journal.pntd.0012708
- Citations
- 3
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 6.14
Funders
- European Commission
- European and Developing Countries Clinical Trials Partnership