Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations
Our findings highlight the interplay between glucose metabolism, erythropoiesis, and skeletal health. The significant associations of HbA1c-variants with both skeletal function and MCHC underscore the potential of these variants to impact broader physiological processes. A large-scale study of African individuals will be essential to unravel genetic variants influencing HbA1c.
Authors
- Oyesola Ojewunmi
- Chisom Soremekun (ORCID: https://orcid.org/0009-0005-9533-0102)
- Daudi Jjingo (ORCID: https://orcid.org/0000-0003-1685-9234)
- Chiara Batini (ORCID: https://orcid.org/0000-0002-7140-2985)
- Harald Grallert
- Homa Bazireh (ORCID: https://orcid.org/0000-0001-5840-7063)
- Oyekanmi Nash (ORCID: https://orcid.org/0000-0002-0796-7834)
- Segun Fatumo (ORCID: https://orcid.org/0000-0003-4525-3362)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Sapna Sharma (ORCID: https://orcid.org/0000-0003-1039-8879)
- David Patrick Kateete
- Amarachukwu Nwagbata
Institutions
- University of Leicester (GB)
- Queen Mary University of London (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Helmholtz Zentrum München (DE)
- Farm Africa (GB)
- Deutsches Diabetes-Zentrum e.V. (DE)
- National Primary Health Care Development Agency (NG)
- German Center for Diabetes Research (DE)
- African Field Epidemiology Network (UG)
- National Biotechnology Development Agency
- Heinrich Heine University Düsseldorf (DE)
- Makerere University (UG)
- Ludwig-Maximilians-Universität München (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1371/journal.pone.0324269
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- London School of Hygiene and Tropical Medicine
- National Institutes of Health
- Medical Research Council
- Helmholtz Zentrum München