Astrocyte-derived extracellular vesicular NFIA mediates obesity-associated cognitive impairment
These findings demonstrated that elevated levels of NFIA packaged within ADEVs contributed to hippocampal synaptic injury under obesity-induced stress condition. The mechanistic insight may provide potential therapeutic targets for addressing obesity-related cognitive decline.
Authors
- Tao Zhu (ORCID: https://orcid.org/0000-0003-2286-9009)
- Zhi Zhang (ORCID: https://orcid.org/0000-0001-6256-9516)
- Shixin Ye‐Lehmann
- Changteng Zhang
- Xiaolin Xu (ORCID: https://orcid.org/0000-0001-8393-2783)
- Ruiqun Wang
- Hailan Chen (ORCID: https://orcid.org/0000-0002-5766-0531)
- Liyun Deng
- Lining Wu
- Rui Gao (ORCID: https://orcid.org/0009-0005-0055-2643)
- Chan Chen (ORCID: https://orcid.org/0000-0001-5823-8247)
- Changliang Liu (ORCID: https://orcid.org/0000-0002-0915-8408)
- Jiahui Wu (ORCID: https://orcid.org/0000-0002-5082-7060)
- Haiqing Chang
Institutions
- University of Science and Technology of China (CN)
- Inserm (FR)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12974-025-03473-9
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China