External validation of the 2023 American Heart Association Predicting Risk of cardiovascular disease EVENTs equations for atherosclerotic cardiovascular disease in primary cardiovascular prevention setting and comparison with 2021 Systematic COronary

Our study confirmed the PREVENT model demonstrated adequate discrimination and calibration capabilities, along with significant clinical utility, particularly at intermediate-risk thresholds. However, it did not outperform the established models, SCORE2 or PCE. Additionally, PREVENT may systematically underestimate risk, which could raise concerns about the underprescription of preventive treatments.